How much does Dupixent cost?

How we calculated these numbers

1. Dosing. The FDA label for adults with atopic dermatitis: a 600 mg loading dose (two 300 mg injections) on day 1, then 300 mg every 2 weeks. That’s 27 injections in year one and 26 a year after. A carton holds two injections, a 4-week supply, so pharmacies dispense 14 cartons in year one (one pen carries over) and 13 a year after. Children’s doses depend on age and weight.¹¹
2. Price. Dupixent’s list price is $4,193.03 per carton (Sanofi and Regeneron, January 2026), the same for the 200 mg and 300 mg doses. Insurance and program costs are figured from that price, one carton at a time.¹
3. Commercial insurance. We run every carton through your plan in order: the deductible first, then your copay or coinsurance, until you reach your out-of-pocket maximum. The table’s low end uses the average specialty-tier copay ($111) with no deductible; the high end uses the average coinsurance (27%) after the average single deductible ($1,886),⁵ capped at the 2026 federal out-of-pocket limit ($10,600).⁸ Averages are from the KFF 2025 Employer Health Benefits Survey; the calculator lets you enter your own plan.
4. DUPIXENT MyWay Copay Card. The card pays your share of each carton down to $0, up to $13,000 per calendar year (the program maximum Sanofi and Regeneron publish). We assume it applies to your full share of each fill and that your plan counts those payments toward your out-of-pocket maximum.¹
5. Medicare Part D. The 2026 standard benefit: a deductible of up to $615, then 25% coinsurance, with total out-of-pocket costs capped at $2,100.⁶ With Extra Help, each brand-name fill costs $12.65 or less.⁹
6. Medicaid. $0 (many states) up to $8 per prescription, the federal limit for a non-preferred drug for enrollees with income at or below 150% of the poverty level, times the number of cartons.⁷ Above that income, states can charge a percentage of the drug’s cost, and all Medicaid cost sharing is capped at 5% of household income.
7. DUPIXENT MyWay assistance. $0 for people the program approves.²
8. Out of pocket. Low end: the list price (wholesale acquisition cost), $4,193.03 per carton of two injections as of January 2026, which the manufacturer says uninsured patients can expect to pay plus pharmacy charges. High end: the national average retail pharmacy price without insurance or discounts, $4,804.99 for a carton of two 200 mg pens, which carries the same list price as 300 mg (GoodRx, September 2026)⁴. We multiply each by the cartons needed: 14 in year one (27 injections), then 13 a year.¹
9. Care costs in the calculator. Honeydew membership starts at $25/month with an annual plan, so we use $25 × 12.³ On a commercial plan, the With Honeydew estimate includes the DUPIXENT MyWay Copay Card, which we help you enroll in; the Traditional estimate uses your plan alone. Traditional care uses four in-office dermatology visits a year (a first visit and quarterly follow-ups), priced the way your coverage pays for them: the average specialist copay ($45, KFF 2025);⁵ Medicare Part B’s 20% of the 2026 fee schedule ($177.36 new visit, $135.61 follow-up, national), with or without the $283 Part B deductible;^12,13 up to $4 on Medicaid (the limit at the lowest income level);⁷ or $100–$300 per visit without insurance (Honeydew’s figure for in-office dermatology).¹⁴ On commercial plans, visit copays count toward the same out-of-pocket maximum as the medication, so they stop once you reach it.