Roflumilast
Treat atopic dermatitis, eczema, and psoriasis with ZORYVE, a steroid-free topical cream. Prescribed online and delivered to you by Honeydew.
ZORYVE cream treats atopic dermatitis, eczema, and psoriasis.
Side effects of ZORYVE are very rare. The most common side effects of ZORYVE cream are:
Do not apply ZORYVE cream to your eyes, mouth, or vagina. Do not use ZORYVE cream if you are pregnant, plan to become pregnant, or are breastfeeding. If you have liver problems, consult with your doctor before using ZORYVE cream.
Honeydew manages your prescription, dosing guidance, and follow-ups, 100% online. Your dermatologist and dedicated care team track progress and coordinate refills, with medication delivered directly to your door.
Fill out a quick medical questionnaire and upload photos of your skin. In many cases, treatment can begin right away without a video consult.
If a visit is needed, you can book a quick video consult within 48 hours. Your provider takes the time to understand your skin and your goals.
Your provider creates a personalized plan, then your treatment is delivered to your door or sent to your local pharmacy.
Track your progress with photos and message your Care Team anytime for questions, refills, and guidance. We'll respond, 7 days a week.
ZORYVE's active ingredient, roflumilast, inhibits phosphodiesterase-4 (PDE4), an enzyme that may play a role in causing conditions like plaque psoriasis and eczema when the body produces it in excess.
By modulating PDE4, ZORYVE balances the skin's immune system to decrease inflammation that drives eczema and plaque psoriasis.
Your dermatology provider will review your skin and confirm whether ZORYVE is the right fit before prescribing.
of patients satisfied with the time it took ZORYVE to start improving their symptoms
of people felt relief from their condition within 4 weeks of using ZORYVE
for best results
Yes. Using ZORYVE with certain medications that inhibit CYP3A4 or both CYP3A4 and CYP1A2 enzymes (such as erythromycin, ketoconazole, fluvoxamine, cimetidine) may increase systemic exposure to roflumilast and potentially increase side effects. Oral contraceptives containing gestodene and ethinyl estradiol may also interact. Tell your healthcare provider about all medications you are taking.
There are limited studies on the use of ZORYVE during pregnancy and breastfeeding. Talk to your healthcare provider to weigh the risks and benefits. ZORYVE should be avoided during labor and delivery. If you are breastfeeding, use ZORYVE on the smallest area of skin for the shortest time needed, and avoid applying it to areas that may come in contact with your baby, such as the nipple area.
ZORYVE is contraindicated in patients with moderate to severe liver impairment (Child-Pugh B or C). You should not use ZORYVE if you have certain liver problems. Talk to your healthcare provider if you have concerns about your liver health.
Yes, wash your hands after applying ZORYVE, unless you are treating your hands. This helps prevent getting the medication in your eyes or mouth.
ZORYVE should be applied once daily to the affected areas. Rub it in completely until it is fully absorbed into the skin.
ZORYVE inhibits the enzyme phosphodiesterase-4 (PDE4), which is involved in the production of pro-inflammatory chemicals in the body. By blocking PDE4, ZORYVE helps reduce inflammation, which relieves the symptoms of skin conditions like psoriasis and dermatitis.
No, ZORYVE is not a steroid. It is a steroid-free topical treatment that works differently from corticosteroids. Because it is not a steroid, it can be used over longer periods of time and on sensitive areas where steroid use may not be preferred.
ZORYVE is a prescription topical medication containing roflumilast, a phosphodiesterase 4 (PDE4) inhibitor. It works by blocking the PDE4 enzyme, which helps reduce inflammation in the skin. ZORYVE is available as a cream and a foam formulation.
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Monthly check-ins help your provider monitor side effects, tolerance, and overall progress throughout treatment.
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If needed, your provider may request baseline or follow-up labs to ensure treatment stays safe and effective.
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Patients who can become pregnant complete required monthly pregnancy testing and iPLEDGE steps, with support at every stage.
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Mood changes are rare but taken seriously. Your provider checks in regularly and adjusts care if needed.
Zero waiting rooms, zero co-pays. Get expert care, personalized treatments, and ongoing support, all online for one transparent price.
Licensed dermatology providers who understand acne beyond the surface and guide your treatment from day one.
We handle prior authorizations, pharmacy communication, and refills so you don't have to.
Upload photos directly to your patient dashboard so you and your provider can monitor how your skin is responding to treatment over time.
Message your provider anytime your skin changes, your prescription needs adjusting, or for anything else.
Honeydew membership is eligible for HSA/FSA spending.
Get expert dermatology care from anywhere in the U.S., with no in-person visits required.
Find more answers in our FAQ or Contact us.
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